' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.7
USERS' SCORE
Very Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
Vitamin D3 may prevent prostate cancer
1,25-Dihydroxyvitamin D Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.
Highly relevant to prostate cancer
We explored how vitamin D3, specifically the metabolite 1α,25(OH)D, influences the behavior of non-cancerous prostate cells derived from African American men. In our study, we treated the RC-77N/E cell line with vitamin D3 and observed significant changes in gene expression after just 24 hours.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
Read More
8
Vitamin D signaling and prostate cancer
Intratumoral vitamin D signaling and lethal prostate cancer.
Highly relevant impact of vitamin D
We assessed how vitamin D signaling within prostate cancer tumors impacts the risk of developing lethal disease. Our focus was on long-term data from two significant health studies involving 404 men diagnosed with prostate cancer. Patients were tracked over decades to see how their tumor characteristics related to vitamin D levels and signaling.
We defined a gene score reflecting the activity of vitamin D signaling based on certain genes that are known to be influenced by vitamin D. When comparing patients who progressed to lethal disease with those who had non-aggressive tumors, we found that a higher vitamin D gene score was linked to a significantly reduced risk of lethal prostate cancer. Specifically, men in the highest quartile of vitamin D signaling were about 54% less likely to develop severe outcomes compared to those in the lowest quartile.
Interestingly, this relationship appeared even stronger for men who had higher predicted levels of vitamin D in their blood or who had a higher body mass index. Our findings give weight to the idea that having active vitamin D signaling in tumors can lead to better outcomes for prostate cancer patients. This motivates further investigation into vitamin D-related interventions that could potentially improve survival rates after a prostate cancer diagnosis.
We defined a gene score reflecting the activity of vitamin D signaling based on certain genes that are known to be influenced by vitamin D. When comparing patients who progressed to lethal disease with those who had non-aggressive tumors, we found that a higher vitamin D gene score was linked to a significantly reduced risk of lethal prostate cancer. Specifically, men in the highest quartile of vitamin D signaling were about 54% less likely to develop severe outcomes compared to those in the lowest quartile.
Interestingly, this relationship appeared even stronger for men who had higher predicted levels of vitamin D in their blood or who had a higher body mass index. Our findings give weight to the idea that having active vitamin D signaling in tumors can lead to better outcomes for prostate cancer patients. This motivates further investigation into vitamin D-related interventions that could potentially improve survival rates after a prostate cancer diagnosis.
Read More
8
Vitamin D3's role in prostate cancer
Vitamin D deficiency aggravates growth and metastasis of prostate cancer through promoting EMT in two β-catenin-related mechanisms.
Direct impact of vitamin D3
We investigated the role of vitamin D3 in prostate cancer growth and metastasis through a series of experiments that involved feeding both nude and Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice with vitamin D-deficient diets. Our findings showed that these mice experienced increased tumor growth along with enhanced invasion and spread of the cancer compared to those on standard diets.
In our laboratory tests, we found that calcitriol, the active form of vitamin D3, successfully inhibited the migration and invasion of prostate cancer cells, whether they were stimulated by transforming growth factor (TGF)-β1 or not. This suggests that vitamin D3 may have therapeutic potential in managing prostate cancer.
Mechanistically, we observed that calcitriol blocked the processes associated with epithelial-mesenchymal transition (EMT), which is crucial for cancer spread. Interestingly, it did not prevent the phosphorylation of specific proteins in the TGF-β1 pathway, indicating that its inhibitory effects are mediated through other means. We found that calcitriol reduced the expression of key genes linked to cancer proliferation and metastasis, while also changing the interactions between important proteins involved in cancer progression.
Overall, our research provides new insights into how vitamin D3 deficiency could worsen prostate cancer outcomes. We believe that understanding these mechanisms could pave the way for better therapeutic strategies in dealing with this disease.
In our laboratory tests, we found that calcitriol, the active form of vitamin D3, successfully inhibited the migration and invasion of prostate cancer cells, whether they were stimulated by transforming growth factor (TGF)-β1 or not. This suggests that vitamin D3 may have therapeutic potential in managing prostate cancer.
Mechanistically, we observed that calcitriol blocked the processes associated with epithelial-mesenchymal transition (EMT), which is crucial for cancer spread. Interestingly, it did not prevent the phosphorylation of specific proteins in the TGF-β1 pathway, indicating that its inhibitory effects are mediated through other means. We found that calcitriol reduced the expression of key genes linked to cancer proliferation and metastasis, while also changing the interactions between important proteins involved in cancer progression.
Overall, our research provides new insights into how vitamin D3 deficiency could worsen prostate cancer outcomes. We believe that understanding these mechanisms could pave the way for better therapeutic strategies in dealing with this disease.
Read More
Most Useful Reviews
8.8
Increased energy
I've been taking this vitamin since my prostate cancer diagnosis on my doctor's recommendation. After nearly 3 months, I've noticed an increase in energy and mood, along with a significant decrease in fatigue. The overall quality of life is still being assessed, but there has been a notable improvement thus far.
Read More
8
Essential for health
This supplement is essential for those in Taiwan who struggle to get enough sunlight. With insufficient sunlight here, D3 supplementation is crucial. My doctor, treating my early stage prostate cancer, recommends 2000IU on a non-daily basis, while others with terminal cancer are advised 5000IU. D3 is vital for post-cancer health and can benefit healthy individuals too.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.7
9
Vitamin D3 may prevent prostate cancer
1,25-Dihydroxyvitamin D Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.
Highly relevant to prostate cancer
We explored how vitamin D3, specifically the metabolite 1α,25(OH)D, influences the behavior of non-cancerous prostate cells derived from African American men. In our study, we treated the RC-77N/E cell line with vitamin D3 and observed significant changes in gene expression after just 24 hours.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
Read More
9
Vitamin D3 enhances cancer treatment
1α,25-Dihydroxyvitamin D synergistically enhances anticancer effects of ginsenoside Rh2 in human prostate cancer cells.
Study shows synergistic effects
We explored how vitamin D3, specifically 1α,25-dihydroxyvitamin D (often called calcitriol), influences the effects of ginsenoside Rh2 on prostate cancer cells. The study focused on both androgen-dependent LNCaP and androgen-independent C4-2 cell lines to analyze if this combination could enhance cancer-fighting properties.
Through various assays, we measured cell viability, proliferation, and the expression of key proteins involved in cancer growth and death. Our findings revealed that when we combined just 10 nM of vitamin D3 with ginsenoside Rh2, there was a marked improvement in reducing cell viability, with some treatments achieving up to an 80% decrease.
Moreover, we noticed that this collaboration also better suppressed the androgen receptor, which plays a significant role in prostate cancer development, while boosting the pro-apoptotic effects of Rh2. This combination suggests that vitamin D3 can potentiate the anticancer potential of Rh2, potentially lowering the required doses of the active vitamin D and minimizing side effects.
Through various assays, we measured cell viability, proliferation, and the expression of key proteins involved in cancer growth and death. Our findings revealed that when we combined just 10 nM of vitamin D3 with ginsenoside Rh2, there was a marked improvement in reducing cell viability, with some treatments achieving up to an 80% decrease.
Moreover, we noticed that this collaboration also better suppressed the androgen receptor, which plays a significant role in prostate cancer development, while boosting the pro-apoptotic effects of Rh2. This combination suggests that vitamin D3 can potentiate the anticancer potential of Rh2, potentially lowering the required doses of the active vitamin D and minimizing side effects.
Read More
8
Vitamin D3's potential in prostate cancer
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Direct investigation on prostate cancer
We investigated the potential of vitamin D3, also known as cholecalciferol, in treating prostate cancer while addressing the concern of toxicity associated with its effective doses. The study utilized a novel approach by encapsulating vitamin D3 in liposomes, which are tiny bubbles made of lipids. This method aims to enhance the effectiveness of vitamin D3 while minimizing its side effects.
Our findings highlighted that the liposomal vitamin D3, referred to as VD-LP, showed improved antitumor activity compared to free vitamin D3. We observed that VD-LP not only delayed tumor growth but also enhanced the survival rates of mice with implanted prostate tumors, specifically using the MC38 model. Remarkably, this treatment did so without causing hypercalcemia, a common concern when administering vitamin D3 at higher doses.
Through careful analysis, we also noted that VD-LP influenced the expression of various genes involved in immune responses and metabolism. This suggests that vitamin D3 could play a role in modulating the cancer environment in a beneficial way. Overall, our research indicates that liposomal encapsulation of vitamin D3 presents a promising avenue for further exploration in prostate cancer therapies, offering both therapeutic efficacy and a better safety profile.
Our findings highlighted that the liposomal vitamin D3, referred to as VD-LP, showed improved antitumor activity compared to free vitamin D3. We observed that VD-LP not only delayed tumor growth but also enhanced the survival rates of mice with implanted prostate tumors, specifically using the MC38 model. Remarkably, this treatment did so without causing hypercalcemia, a common concern when administering vitamin D3 at higher doses.
Through careful analysis, we also noted that VD-LP influenced the expression of various genes involved in immune responses and metabolism. This suggests that vitamin D3 could play a role in modulating the cancer environment in a beneficial way. Overall, our research indicates that liposomal encapsulation of vitamin D3 presents a promising avenue for further exploration in prostate cancer therapies, offering both therapeutic efficacy and a better safety profile.
Read More
8
Vitamin D signaling and prostate cancer
Intratumoral vitamin D signaling and lethal prostate cancer.
Highly relevant impact of vitamin D
We assessed how vitamin D signaling within prostate cancer tumors impacts the risk of developing lethal disease. Our focus was on long-term data from two significant health studies involving 404 men diagnosed with prostate cancer. Patients were tracked over decades to see how their tumor characteristics related to vitamin D levels and signaling.
We defined a gene score reflecting the activity of vitamin D signaling based on certain genes that are known to be influenced by vitamin D. When comparing patients who progressed to lethal disease with those who had non-aggressive tumors, we found that a higher vitamin D gene score was linked to a significantly reduced risk of lethal prostate cancer. Specifically, men in the highest quartile of vitamin D signaling were about 54% less likely to develop severe outcomes compared to those in the lowest quartile.
Interestingly, this relationship appeared even stronger for men who had higher predicted levels of vitamin D in their blood or who had a higher body mass index. Our findings give weight to the idea that having active vitamin D signaling in tumors can lead to better outcomes for prostate cancer patients. This motivates further investigation into vitamin D-related interventions that could potentially improve survival rates after a prostate cancer diagnosis.
We defined a gene score reflecting the activity of vitamin D signaling based on certain genes that are known to be influenced by vitamin D. When comparing patients who progressed to lethal disease with those who had non-aggressive tumors, we found that a higher vitamin D gene score was linked to a significantly reduced risk of lethal prostate cancer. Specifically, men in the highest quartile of vitamin D signaling were about 54% less likely to develop severe outcomes compared to those in the lowest quartile.
Interestingly, this relationship appeared even stronger for men who had higher predicted levels of vitamin D in their blood or who had a higher body mass index. Our findings give weight to the idea that having active vitamin D signaling in tumors can lead to better outcomes for prostate cancer patients. This motivates further investigation into vitamin D-related interventions that could potentially improve survival rates after a prostate cancer diagnosis.
Read More
8
Vitamin D3's impact on prostate cancer
1,25(OH) D induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Strong relevance to prostate cancer
We explored the effects of 1,25(OH) D, an active form of vitamin D, on prostate cancer cells, particularly focusing on its ability to influence endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling. Previous research highlighted that the vitamin D receptor (VDR) decreases in many cancer types, including prostate cancer, prompting our investigation into how vitamin D3 could be a potential ally against tumor growth.
Our findings revealed that vitamin D3 negatively impacts ERAD components, playing a role in the unfolded protein response (UPR) within LNCaP human prostate cancer cells. Interestingly, we noted a dual regulatory effect where VDR signaling inhibited androgen signaling, suggesting that it may limit the cancer's ability to progress. This was further supported by molecular docking studies indicating that vitamin D3 could effectively inhibit androgen receptor activity.
Additionally, we discovered that VDR signaling appears to impede tumor progression by lowering levels of c-Myc, a protein often associated with cancer advancement, and reducing the epithelial-mesenchymal transition (EMT). Furthermore, treatment with vitamin D3 significantly hampered the formation of three-dimensional tumor structures in LNCaP cells, hinting at its practical uses in inhibiting tumor growth.
Overall, our investigation indicates that deeper understanding of VDR signaling could open doors to enhanced therapies for various cancers, including how estrogenic signals affect breast cancer. The data suggests that vitamin D3 could provide valuable benefits in prostate cancer treatment, particularly in slowing its progression through multiple mechanisms.
Our findings revealed that vitamin D3 negatively impacts ERAD components, playing a role in the unfolded protein response (UPR) within LNCaP human prostate cancer cells. Interestingly, we noted a dual regulatory effect where VDR signaling inhibited androgen signaling, suggesting that it may limit the cancer's ability to progress. This was further supported by molecular docking studies indicating that vitamin D3 could effectively inhibit androgen receptor activity.
Additionally, we discovered that VDR signaling appears to impede tumor progression by lowering levels of c-Myc, a protein often associated with cancer advancement, and reducing the epithelial-mesenchymal transition (EMT). Furthermore, treatment with vitamin D3 significantly hampered the formation of three-dimensional tumor structures in LNCaP cells, hinting at its practical uses in inhibiting tumor growth.
Overall, our investigation indicates that deeper understanding of VDR signaling could open doors to enhanced therapies for various cancers, including how estrogenic signals affect breast cancer. The data suggests that vitamin D3 could provide valuable benefits in prostate cancer treatment, particularly in slowing its progression through multiple mechanisms.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 2 Reviews
8.7
8.8
Increased energy
I've been taking this vitamin since my prostate cancer diagnosis on my doctor's recommendation. After nearly 3 months, I've noticed an increase in energy and mood, along with a significant decrease in fatigue. The overall quality of life is still being assessed, but there has been a notable improvement thus far.
Read More
8
Essential for health
This supplement is essential for those in Taiwan who struggle to get enough sunlight. With insufficient sunlight here, D3 supplementation is crucial. My doctor, treating my early stage prostate cancer, recommends 2000IU on a non-daily basis, while others with terminal cancer are advised 5000IU. D3 is vital for post-cancer health and can benefit healthy individuals too.
Read More
